It can be crucial to reliable performance while running Windows applications using WINE to use separate wineprefixes for potentially difficult programs you’re using–the more complex the software, the more you need to make a separate wineprefix for it.
The example Windows software we’ll install to run under WINE is the popular free program Irfanview.
Make the new wineprefix (this is equivalent to making a totally separate install of Windows, except that it’s really fast and takes about 355MB)
env WINEPREFIX=~/.wine_irfanview winecfg
Install your program (in this case, Irfanview)
env WINEPREFIX=~/.wine_irfanview wine iview_setup.exe